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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: Seventh Reference for Environmental Parkinsons - Pollutant Botulism - Clostridium Botulinum > Date: Tuesday, July 06, 1999 11:40 AM > > Map of Parkinsons Diseases > > Biochemical Pathways Map No. O10 P10 - Aerobic Respiraton of Mitochondria > > Complex I - NADH - FAD - Quinone > NADPH OXIDASE - NADH (NADH supplements for Parkinsons) > (CoQ10 supplements for Parkinsons) > NADPH OXIDASE - RAC - RAC3-Clostridium Botulinum > RAC3 - Bcr-breakpoint cluster - RARA - Retinoic Receptor - > Retinoid X receptor - TARGRETIN - ALRT drugs > Bcr- Parkinsonian Birth Defects - Color Blindness & > Olfactory caused by cRA N-nitrosodimethylamine > NADPH OXIDASE - RASrelated - RAS3- ADP (adenosine > diphosphate) ribosylation - CREB-CREB2 > NADPH OXIDASE - clostridium botulism - CXX-COOH-Cytochrome > b 558 - cytochrome c > NDUFV2 Mutation - no NADH - Parkinsons Disease > FAD - Rotenone - Mutation of FAD - Parkinsons Disease > > Complex II - Succinate Dehydrogenase - Part of Citrate Cycle or > Tricarboxylic Cycle > Succinyl CoA - cAMP or cyclic Adenosine Monophosphate > cAMP - ethyl carbamate - dithioethylcarbamate - caspase > inhibitor- enhanced MPTP- synthetic drug Parkinsons Disease > cAMP- adenyl cyclase- Pertussis - prone to Parkinsons > Disease in old age > CREB - cis response element of cAMP (Retinoic) > CREB - Proenkephalin (Enkephalin and D2 Dopamine > Receptors) and TCL4 (Cutaneous lymphoma or Cancer) > CREB - Targretin is for Nitrosodimethylurea induced TCLC > breast cancer > CREB2 - CREB > CREB2 - C/EBP - Myeloperoxidase Promoter - Lipid > Peroxidation > Increased Lipid Peroxidation - 4HNE mutation Parkinsons > Disease > - SOD1 and SOD2 > Lewy Body Parkinsons Disease > - ALPHA > SYNUCLEIN - Park 1,2,3 Parkinsons Diseases (Increased Threonine causes > increased lipids into the brain causing increased lipid peroxidation and > Parkinsons Disease > - APOE4 - > Apolipoprotein Mutation - Parkinsons Disease > - Pelizaeus > Merzbacher - Parkinsons Disease > CREB-CREB2- Retinoic Acid Binding Protein -CCAAT or CUTL1 > or Caspase-1 > CCAAT-AAT-Elevated in Parkinsons- Mutation causes > Alzheimers Disease > AAT-Transglutaminase - Huntingtin- N-Nitrosodimethylamine > and Dimethylamine inhibition - Environmental Parkinsons > CREB-CREB2-CRAB2- Nicotinic-acetylcholine receptors Acra > (Alpha chain) and Catalase (Cas-1) > CYP 450 - Metabolizes Retinoic Acid - > N-Nitrosodimethylamine - Mutation of CYP450- Parkinsons Disease > CRAB2- Acetylcholine Receptor - Homogentisic Acid ( > Benzoquinone Acetic Acid )- Alkaptonuria Parkinsons Disease > - > Homovanillic Acid L205- Parkinsons Disease > > Complex III - Rieske Mutation - Parkinsons Disease > Increased iron in blood - Parkinsons Disease > Increased Manganese - SOD2 - Parkinsons Disease > Cytochrome C - Human growth factor - Stem Cells - GDNF - > Glial Derived Growth Factor - RXR-RAR Orphan Receptors > RXR Mutant Mice - Parkinsons Locomotion - Targretin > > Complex IV - Cytochrome C Oxidase - Iron - Metallic ions bond with > N-Nitrosodimethylamine and Dimethylamine > > Complex V - nH - ATP - ADP - Nadph Oxidase - N-Nitrosodimethylamine - > uncoupling protein in brown fat cells > > [log in to unmask] >