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I was wondering if Permax can be used as monotherapy (without Sinemet). Both Requip and Mirapex have been touted as this, but can the earlier agonists such as Permax also do the job alone? Does Permax have a lower "fatigue" factor? Joe has been taking 3 mg of Mirapex as monotherapy and also experiences a lot of fatigue. Don't know if it's a result of PD itself, or the Mirapex, or a combination. Ann Gibbons cg Joe 65/2