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Hi Jeannette--yes, I have been following the discussion about switching to Permax, but all those who replied are also taking Sinemet, which is why I raised the question of Permax as monotherapy. And Judith--ask and it will be answered! Thanks very much for printing the article on Permax as monotherapy, as well as the URL for the drug database. And Camilla--yes, I think it's hard to sort out what the real source of the fatigue is. I think Janet Paterson mentioned recently that fatigue is simply one of the major symptoms of PD. Some probably get more fatigue than others. I would mention again that there is a new med, approved by the FDA 12/98, called Provigil. It's an anti-narcoleptic, and Phil Tompkins has pointed out that it's in clinical trials for PD and MS fatigue symptoms. Joe has tried it and we really can't see a lot of difference, but for the last 8 months Joe has been in constant pain from that *+%( non-PD surgery he had. That alone is truly tiring, so it's not a fair test. Ann Gibbons cg Joe 65/2 Ann Gibbons