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Exercise performance in those having PD and healthy normals. OBJECTIVE: This study assessed and compared the cardiopulmonary function of individuals with Parkinson's disease (PD) with that of healthy normals (HN) in order to provide health professionals with more thorough information about the problems associated with PD. METHODS: 20 men (PD = 13, HN = 7; mean age 64 and 64, respectively) and 23 women (PD = 7, HN = 16; mean age 65 and 66, respectively) were recruited from the Houston metropolitan area. Maximal oxygen consumption (VO2max mL x kg(-1) x min(-1)) and time to maximal exercise in minutes (time(max)) were measured. Exercise was performed on a stationary bicycle using an incremental exercise protocol. Because the assumption of homogeneity of variance was not met for the dependent variable VO2max in women, the nonparametric Wilcoxon-Mann-Whitney-U analysis was used (alpha < or = 0.025). All other group comparisons were analyzed using an independent t-test (alpha < or = 0.025). RESULTS: For men and women, there were no significant differences in VO2max between those having PD and the HN: (men: PD = 23.52 vs HN = 25.46 mL x kg(-1) x min(-1), P = 0.50) (women: PD = 20.10 vs HN = 16.20 mL x kg(-1) x min(-1), P = 0.35) Likewise, there was no significant differences in time(max) between women: (PD = 5.2 vs HN = 5.4 min, P = 0.20). Comparison of time(max) between men did show a significant difference: (PD = 9.5 vs HN = 13.10 min, P = 0.02). CONCLUSIONS: Although there were no significant differences in VO2max between the men, the comparison of time(max) indicates those with PD were unable to exercise as long before reaching VO2max, indicating that individuals with PD may be less efficient during exercise and therefore unable to exercise as long before reaching VO2max. Although women with PD had a higher VO2max, comparisons of VO2max and time(max) between those with PD and HN resulted in no significant differences. Med Sci Sports Exerc 1999 Jun;31(6):761-6 Stanley RK, Protas EJ, Jankovic J University of Maryland School of Medicine, Baltimore 21201-1082, USA. [log in to unmask] PMID: 10378900, UI: 99305245 http://www.ncbi.nlm.nih.gov/PubMed/ janet paterson 52 now / 41 dx / 37 onset snail-mail: PO Box 171 Almonte Ontario K0A 1A0 Canada website: a new voice <http://www.geocities.com/SoHo/Village/6263/> e-mail: <[log in to unmask]>