hi all "apoptosis" is one of the first medical terms i learned in re pd it means "cell death" which is what is happening in my and your substantia nigra the cause of which is as yet unknown so if i see apoptosis mentioned in a medical abstract i tend to sit up straight and pay attention "mediate" is not strictly a medical term but plays a role in the jargon that fills the journals it means "reduces" now, when i see "apoptosis" and "mediates" in the same sentence and that sentence is talking about dopamine and pd no longer sitting, i am standing at attention! janet janet paterson 52 now / 41 dx / 37 onset snail-mail: PO Box 171 Almonte Ontario K0A 1A0 Canada website: a new voice <http://www.geocities.com/SoHo/Village/6263/> e-mail: <[log in to unmask]>