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Dear PWP, Are any of you out there taking coenzyme Q10 or NADH? and if you are how much are you taking, and when do you take it .....along with your regular meds for PD? or at a separate time during the day? Has anyone out there benefited by taking either of these supplements and if so how? And, has anyone been able to lower their sinemet intake due to taking either coenzyme Q10 or NADH? If anyone has any info about either of these ie. research being done with either? articles that anyone has read related to these? any info at all, I would be so interested in hearing from you. One more thing.....I recently read that sinemet loses its effectiveness in temperatures of 80 degrees Fahrenheit or more. In this heat has anyone noticed this happening ? and should we store our sinemet in the refrig if this is the case? thank you! thank you! Patsy Manning (age 53, diagnosed at age 42, symptoms began when I was 39)