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Hans and all list family who replied to my query re:Mirapex switch to Permax: I appreciate all the comments and advice sent by each of you. I'll be starting PERMAX for a trial next week after my company leaves. I'll post to list after the trial period and let you know if PERMAX as a monotherapy for my early pd works for me. Thanks, Jeanette Fuhr 48/47/44? ---------- > From: Hans van der Genugten <[log in to unmask]> > To: [log in to unmask] > Subject: Re: Mirapex switch to Permax(pergolide/meysylate) > Date: Thursday, July 08, 1999 8:04 PM > > -----Oorspronkelijk bericht----- > Van: Leo Fuhr <[log in to unmask]> > Aan: [log in to unmask] <[log in to unmask]> > Datum: donderdag 8 juli 1999 13:44 > Onderwerp: Re: Mirapex switch to Permax(pergolide/meysylate) > > > Hi Jeanette, > > >> Since Mirapex is making me extremely sleepy << > > I have had the sleepy feeling and the sudden sleep attacks with REquip. > Since I stopped it a few weeks ago it disappeared completely again. > > > > He suggested a month's trial with the agonist Permax because at age 48 > and with mild symptoms of PD(left side slowness, fatigue, small writing and > > > trouble with small motor skills) he wanted to delay Sinemet awhile > longer. << > > I used Permax for about 2 years, no sleepy feeling. > The neuros advice is IMO a good advice. > > Permax or Sinemet: > - the long term side effects are well known (dyskinesia). > - recent study found that dyskinesia is more frequent in women than in man. > - as far as is known now long term Permax use gives no dyskinesia. > - a certain level of dose Permax can stay longer at the same level, but an > comparible dose of Sinemet with the same effects needs to be raised faster > to maintain those effects. (long time wearing off). > > Hans.