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Hans, IMHO I have to disagree with you about the meaning of mediates. I don't believe it refers to as you suggest bringing back to the median hence normal I think it is referring to the meaning of the word "mediate" as used in the word "mediator" or a go-between. Like an arbitrator it is a step in the middle which has an effect on the outcome. It may bring things back to a normal state but doesn't have to to "mediate". Charlie Hans van der Genugten wrote: > -----Oorspronkelijk bericht----- > Van: Charles T. Meyer, M.D. <[log in to unmask]> > Aan: [log in to unmask] <[log in to unmask]> > Datum: zaterdag 10 juli 1999 20:05 > Onderwerp: Re: PMID: silliness two [but important] > > Hi Charlie and Janet, > > IMO the "apoptosis" article is saying the following: > > - PD is not caused by apoptosis of cells in the substantia nigra, but by an > INCREASED apoptosis. > - a endogenous neurotoxin "B" is found in HIGHER levels in PWP. > - "Mediate" means "bringing back to standard/normal values". > - "Mediate" doesn't mean that "A" REDUCES the apoptosis induced by "B", > because that would mean that eventually apoptosis could be reduced to ZERO. > - Conclusion: "A" can bring the INCREASED apoptosis, that is caused by > INCREASED levels of "B", back to STANDARD values of apoptosis induced by > STANDARD values of "B". > > Hans. -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************