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---------- > From: Sharon & Jim LeBlanc <[log in to unmask]> > To: [log in to unmask] > Subject: PMID 10380999 Caspase-3 - Parkinsons, Caspase -1, Huntingtons, Environmental Parkinsons yet another reference > Date: Monday, July 12, 1999 12:54 PM > > I have an unusual family. We have both parkinsons disease and huntingtons > disease. My husband has parkinsons, my step-children are at risk for > Huntingtons. > Huntingtons disease is a disease of overproduction of glutamine and the > formation of amyloid fibers similiar to Alzheimers disease. > It will affect my family when the kids turn 30. > May 1999 Dr Anne Young and Dr Penny, who was our MD until his recent death, > published on Pub Med and article on how Inhibition of Caspase-1 slowed > down the progression of Huntingtons Disease. Caspase-1 cuts the chains of > Huntingtin protein attached to glutamine, making globs that eventually kill > the brain cells. > Caspase-1 can be slowed down by GSSG:GSH and GSH or glutathione is in the > health stores. GSSG or glutathione reductase which resupplies GSSG can be > taken from plasmodium falcaripum or malaria, but I don't know if it is > produced by anyone. > I sent you a copy of Caspase-3 and its relationship to Parkinsons Disease. > Huntingtin is a subset of, transglutaminase. > Huntingtons Disease is an overexpression of transglutaminase. > Peter Davies is doing research on retinoids and has identified two > retinoids that regulate transglutaminase. > Retinoids inhibit, these retinoids if manufactured could inhibit > Huntingtin, maybe cure the disease. I sent the info to the Huntington's > Disease Society in my area. > If you give Huntingtonians too many meds they become Parkinsonian, rigid > and stiff. > If you give Parkinsonians too many meds they become Huntingtonian, their > limbs wiggle and dance, chorea, tardive dyskinesia. > Peter Davies says transglutaminases bind with Retinoid X and RAR receptors. > Retinoid X mutant mice are blind and have Parkinsonian locomotion, per pub > med. > Dimethylamine becomes N-nitrosodimethylamine in air and inhibits > transglutaminase and inhibits insulin receptors. > Inhibit transglutaminase, inhibit retinoid X, Parkinsons. > Targretin is a retinoid X receptor agonist, booster, and is for > N-nitrosomethylurea cancer and diabetes II. > CREB1 or cis response element 1 is a retinoic for proenkephalin or D2 > receptors and TCL4 cancer > CREB2 binds with C/EBP peroxidase promoter and Parkinsons is an > overproduction of lipid peroxidation. > My husband has Parkinsons, his twin , breast cancer. > cRA cause craniofacial birth defects, and Parkinsonians have blue-yellow > color blindness and olfactory birth defects. > I searched for cRA and got Dimethylamine and N-Nitrosodimethylamine. > Fluctuations in Transglutaminase explains the connection between Parkinsons > and Alzheimers and Dementia Parkinsons that seems to contain both diseases. > [log in to unmask] >