FDA To Study Whether Clozapine Can Cause Diabetes
WESTPORT, Jul 14 (Reuters Health) - Data presented at The Endocrine Society
meeting, held recently in San Diego, suggest that the antipsychotic agent
clozapine (Clozaril) may cause new-onset diabetes mellitus.
Dr. Elizabeth Koller, of the FDA Center for Drug Evaluation & Research,
Rockville, Maryland, reported that she and associates at the Center have
gathered data on 205 cases of onset or exacerbation of diabetes in
clozapine-treated patients.
In a telephone interview after the meeting, Dr. Koller told Reuters Health
that the first published report she saw caught her attention because "...the
presentation was unusual--the age of the patient and the severity of the
hyperglycemia."
From MEDLINE, Dr. Koller and her colleagues retrieved a total of 11 similar
published case reports of clozapine-associated diabetes involving 18
patients. They identified 124 additional cases by reviewing reports that
were submitted to the FDA MedWatch surveillance program between 1993 and
1998. <SNIP>
http://ipn.intelihealth.com/ipn/ihtIPN?c=232989
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Judith Richards, London, Ontario, Canada
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