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At 19:23 5-7-99 +0200, you wrote: >Just a perhaps silly question: if dyskinesia can be a sign of too much >L-dopa, what are the signs of too much agonist? >Maryse Maryse, It's not a silly quwstion at all. I realised reading at, I did not know the answer. But today i met with this article. Rev neurol(Paris) 1977 Aug-sep; 133(8-9):445-54 [ Abnormal movements* caused by L-Dopa and O-methyl-Dopa] [Article in French} Lhermitte F, Agid Y, Feuerstein C, Serre F, Signoret JL, Studler JM, Bonnet AM This study involved twelve parkinsonian patients exposed to abnormal movements provoked by L-dopa. Including six patients with mid-dose dyskinesias and six others with onset and end of dose dyskinesias. Correlation between the circum- stances of onset of abnormal movements and plama concentrations of DOPA and O- methyl- DOPA, after administration of a dose of L-DOPA + IDC(I don't know what IDC is, Ida ), gave the following results: 1) mid-dose dyskinesias appeared with the highest plasma concentrations of DOPA , at the maximum therapeutic effect; 2)onset and end of dose occured during rise and fall in plasma levels of DOPA, coinciding with the relief and the reappearance of parkinsonian symptoms respectively; 3)no correlation could be established between plasma concentrations of O-methyl-DOPA and the duration of the periods of clinical remission or of abnormal movements. These biochemical data, completed by the neuropharmacological study of one patient with onset and end of dose abnormal movements suggest the predominant role of a disturbance in central dopaminergic mechanisms in the genesis of abnormal movements, whatever their nature. PMID: 929037, UI: 78054363 *The words Abnormal movements in stead of dykinesias is used, because the original aricle is in french and in french dyskinesia is "mouvements anormeaux" SO it says that he level of dopamine causes only the onset of the mid dose dyskinesia not the time it lasts and not one of these variables in diphasic dyskinesia. My own experience is that taking less sinemet even can cause more onset or end of dose dyskinesia. The question what "the distubance in central dopaminergic mechanisms" is, has yet not been answered. I think THE SIGHN for overdose of agonists does not exist. Ida -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]