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At 09:28 18-7-99 -0700, J. R. Bruman wrote: I wonder if the hand and foot tremor that appears a few minutes after the scheduled dose of Sinemet could be a form of peak-dose dyskinesia, and whether it could be associated with agonists such as Requip as well. At this point, it's noticeable but not very >troublesome, and subsides within a half hour or so. Might not occur if >I substitute Sinemet CR for the regular Sinemet, to damp out the >response. Cheers, >Joe Joe, I am puzzled by this mail of yours. You wonder if the tremor, that you mention could be a form of peak-dose dyskinesia, but your description of the time and conditions in which it manifests itself are most like those of start of dose reaction, though a very quick one if it appears only a few minutes after the scheduled dose of sinemet. If it is a start of dose reaction, it might occur also, but would decline more quickly. The instruction leaflet of Requip says that and dyskinesia are among the possible side effects of Requip. Tremor is not mentioned as such. But you never can tell with Parkinson..... A few months ago I could hardly believe my own observation about the timing of my speech problems: soft voice and bad articulaton, which nowadays appear as soon as my meds are maximum effective against my other symptoms and disappears as soon as my other motor functions leave me. Ida -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]