Ida & Maryse: Thanks for the question and the reply about dyskinesia and it's possible connection to dosage of agonists. The information helps me know I'm not driving myself crazy trying to pinpoint my husband's experiences with dyskinesia, which seem to have no set pattern of arrival (mid-dose sounds like what he is having mostly, but I had only heard of end of dose cases), so the timing of the arrival of his difficult times has been unpredictable for us. I am realizing that he is becoming more and more sensitive to inerval fluxuations , thus we are hoping to move into the agonist world (been using Bromocriptine the past 6 mo.- can't tell any significant benefit). I too have been wondering what effects the agonist have and what part they play in the dyskinesia, difficulty with talking, and freezing specifically. We have an appt. with Neuro. Aug. 5th and hope to ask some challanging questions and press for more specific answers. Right now I'm leaning toward asking to have a prescription for Mirapex to try - but my husband is inclined to stay with our same current program - though I can see he's progressing and feel that his quality of life can still be enhanced greatly if we can only make the right choices in medication and lifestyle...... If we come up with more difinitive ideas about agonists and dyskinesia we'll be posting the news...... marie carepartner for husband 70/l3 As Don and others remind us.......Best med for PD - NEVER GIVE UP!