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To Nigel: My name is Carol Walton and I am a member of the Parkinson Alliance Executive Committee--I am usually silent on the listserv but I am catching up on e-mail having just returned from the East--I was told by one of the drug companies that there can be at 20% difference --plus or minus--when different companies make generic drugs--therefore you could be taking a brand name drug--switch to a generic and have a 40% difference--some companies and now trying to set a standard since this can be devastating especially with Parkinsons medications--I hope some others answer you also since I am not an expert in any way shape or form--but I hope this helps and you might run this by your pharmacist--good luck--carol walton