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The June 7, 1999 issue of the New Yorker magazine has a long profile article about Dr. Harold Varmus, CEO of the NIH. He is a political appointee of Clinton, brought in by Donna Shalala. His thinking has done much to set the course of the NIH in the direction of so called pure research, rather than as earmarking for specific diseases. PWP, unfortunately live in the immediacy. A case may be made for both approaches. Why not a compromise, e.g., putting more money where there is a clinical payoff in sight? Dr..Varmus is personally health conscious, a free wheeling spirit, he rides his bike to work. Good for a healthy body, and self concept.