From PBS on Line : --------- What's Being Done in Parkinson's Research? The recent explosion of biomedical research has introduced several exciting developments in the search for a cure for or treatment for Parkinson's disease. One of the most common diseases of old age, Parkinson's disease is believed to affect about 1 million Americans. Parkinson's disease research focuses on many fronts. Some investigators are looking at the musculoskeletal system and how it is regulated by the brain. Others are trying to find a link between the disease and environmental factors, such as toxins that may trigger the disorder, or defective genes. Meanwhile, some scientists are trying to prevent or reverse the disease with protective drugs. In INNOVATION: LIVE LONG AND PROSPER, Dr. Anthony Arthur, a dental surgeon, was implanted with an electrode that would stimulate cells deep in the brain, in the area called the subthalamic nucleus, to make them more receptive to dopamine. In this cutting-edge therapy, offered at Mount Sinai Medical Center in New York City, the electrode is connected to an assistive device, similar to a heart pacemaker, that is surgically implanted under the collarbone. After some fine tuning, the device seemed to produce enough relief from tremors and other symptoms that the man could lead a nearly normal life. More recently, the French researchers tried implanting the electrodes specifically into the subthalamic nucleus; this technique seems to cause improvement in a wide range of symptoms. In 1995, they reported in the medical journal LANCET that they had done the procedure on three patients. Three months later after surgery, they said, the patients' motor abilities had improved 42 to 84 percent, as measured on standard tests, and their ability to do the activities of daily life had improved 58 to 88 percent. In August, 1997, the Food and Drug Administration (FDA) approved the brain implant, which previously had been used only experimentally. At that time, fewer than one hundred patients in the United States had undergone deep brain stimulation, and in only a fraction of those cases had the implant been done in the subthalamic nucleus. In granting approval, the FDA required Medtronic Inc. of Minneapolis, which makes the implant technology, to study the long-term effects of constant electrical stimulation on brain tissue. According to the National Institute of Neurological Disorders and Stroke, another promising treatment method involves using an implanted pump or implanting capsules containing dopamine-producing cells into the brain. The capsules are surrounded by a biologically inert membrane that lets the drug pass through at a timed rate. At Columbia University, researchers are genetically engineering dopamine receptors in transgenic mice to better understand the mechanisms of the disease and develop novel therapies for Parkinson's. At the University of Virginia and the University of Colorado, rhesus monkeys have been given a growth factor called glial-cell-line-derived neurotrophic factor, or GDNF, to see if they can regrow damaged dopamine-producing nerve cells. So far, the results have been promising. In Massachusetts, Genzyme Corp., Tissue Repair Division and Diacrin, Inc., are working on the development of porcine transplants. Researchers will transplant healthy nerve cells from pigs into human brains to restore damaged neural circuits. This xenograft — or cross-species transplant — therapy is being tested at several major medical centers. Neural transplantation is an experimental technique proposed for treating the disease. A federally-sponsored trial of neural transplants using human fetal tissue is being done at three research universities, including Columbia University. The goal is to replace lost or damaged dopamine-producing neurons with healthy, fetal neurons. Another promising approach may be the use of genetically engineered cells, such as skin cells, that could carry neurons to the affected site. These might even come from the patient's own body and be replicated in tissue culture. The search for more effective medications for Parkinson's disease is likely to be aided by the recent isolation of at least five individual brain receptors for dopamine. And, in 1996, NIH scientists reported finding the general location of a gene that may be responsible for some cases of familial Parkinson's disease. This gene may not be responsible for all Parkinson's, but it may help scientists understand more about the nature of the disease. -- ------------------ Cheers , +----| Joao Paulo de Carvalho |------ + | [log in to unmask] | +--------| Salvador-Bahia-Brazil |------+