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Lancet: Volume 354, Number 9173 10 July 1999 Nigral endothelial dysfunction, homocysteine, and Parkinson's disease Thomas Müller, Brigitte Werne, Brian Fowler, Wilfried Kuhn We found increased levels of atherosclerosis-inducing homocysteine in parkinsonian patients with long-term application of levodopa compared with previously untreated parkinsonian patients and controls. We conclude that antiparkinsonian treatment with levodopa promotes occurrence of vascular disease in Parkinson's disease. ---------------------------------------------------------------------------- ---- Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany (T Müller MD, B Werne MD, W Kuhn MD); and University Children's hospital, Basel, Switzerland (B Fowler MD) ---------------------------------------------------------------------------- ---- Correspondence to: Dr Thomas Müller (e-mail: [log in to unmask])