It seems to me that almost everyone is missing the point about this non-event. I will try again to convey the points which are really irritating me. 1/ SmithKline Beecham have made NO major breakthrough. 2 SmithKline Beecham have simply re-stated what we have all known for the past 5 years: that the Dopamine Agonists from Permax on are capable of acting like dopamine to the nervous system, without increasing the risk of dyskinesia. (My tablet strategy has been based on this fact for the last 5 years. 3/ I admit to a grudging respect at SKB's nerve at wrapping the package so that it fools (apparently) just about everyone at the conference. 4/ Alternatively (and very scary) - it may be that SKB really believed the results of their 'research'. Could this be true? . The bottom line seems to be that SKB have fooled a convention-hall full of specialists, or they have fooled a convention-hall full of specialists AND themselves. (And if this sounds like the famous old question 'Have you stopped beating your wife?' - GOOD!) -- Brian Collins <[log in to unmask]>