JUL 30, 1999, M2 Communications - Vancouver, Canada -- Reports of Parkinson's disease affecting public figures such as Janet Reno, Michael J. Fox and Muhammad Ali have increased awareness of the prevalence of the disease and its impact on patients' lives. Now a landmark study released this week at the 13th International Congress on Parkinson's Disease in Vancouver shows that SmithKline Beecham's drug Requip (ropinirole hydrochloride) successfully manages Parkinson's disease and significantly lowers the risk of developing dyskinesias, involuntary body movements which are often associated with levodopa, a common Parkinson's disease therapy. The study is the first five-year, double-blind trial of a dopamine agonist versus levodopa. The study was designed to measure the incidence of dyskinesias and efficacy as assessed by activities of daily living. Researchers sought to evaluate if Requip could successfully manage symptoms in patients with early-stage Parkinson's disease and delay the need to initiate levodopa treatment for up to five years. Levodopa has been the "gold standard" of treatment in Parkinson's disease for the past 35 years; it is used in approximately 75 percent of patients. Unfortunately, over time Parkinson's disease progresses and physicians need to increase the dosage and frequency of levodopa to relieve Parkinson's symptoms. Increasing the dose of levodopa can cause many patients to experience levodopa-induced side effects such as irreversible dyskinesias, which can have a negative impact on a patient's ability to function. "The study results released this week demonstrate that early stage Parkinson's disease (Hoehn & Yahr disease stages I-III) can be successfully managed for up to five years using Requip as first-line treatment," said lead study author Olivier Rascol, M.D., Ph.D. of the Centre Hospitalier Universitaire Toulouse, France. "In this study, using Requip and a low dose of levodopa, when necessary, reduced the risk of developing dyskinesias that are often associated with levodopa therapy. This is the most compelling data seen to date in support of early treatment with a second-generation dopamine agonist, and the results can affect the future management of Parkinson's disease." One Woman's Story: From Uncomfortable Dyskinesias to A Life with Greater Symptom Control A teacher and avid fan of jigsaw puzzles, gardening and cooking, Helen Collins lived a busy and fulfilling life until her left hand and leg began to tremble uncontrollably. In 1980, embarrassed by her irrepressible movements, Helen went to the doctor. After five years of visits to numerous doctors and a battery of tests, at the age of 55 Helen was finally diagnosed with Parkinson's disease. Drained of energy, she found that her favorite activities such as water exercises and playing bridge became too physically difficult to perform and she lost interest in doing the things she loved -- socializing, eating out and gardening. Initially, Helen was placed on levodopa in combination with amantadine to control her Parkinson's disease. These medications did manage her symptoms; however, she gradually began to experience uncomfortable motor complications (e.g., shaking, involuntary movements, dry mouth, a tendency to grimace and the freezing effect). Twelve years after her diagnosis, Helen's right side began to display the same symptoms as her left. In 1998, Helen's doctors re-evaluated her medication and added Requip and selegiline to her regimen. Since that time, Helen says, "Requip has helped to control my Parkinson's disease symptoms." With her dyskinesias occurring less frequently and for shorter spans of time, Helen is back to doing many of the activities Parkinson's disease forced her to give up. "Requip lets me be more active," says Helen. "I can drive again and lead a more normal, better life with Parkinson's disease. I am planning to live until we find a cure for Parkinson's and will fight back against the disease and live my life to the fullest," she says. Requip Effective Long-Term Therapy In a double-blind, parallel-group study, 268 patients with early Parkinson's disease were randomized (2:1) to receive either Requip or levodopa, and were evaluated for five years. The study evaluated the incidence of dyskinesias. Patients in both the Requip and levodopa groups whose symptoms did not improve were given supplemental levodopa. The incidence of dyskinesias experienced during the course of the study and amount of levodopa added to their treatment regimen were evaluated. Of those enrolled, 130 patients completed the study (n=85 Requip, n=45 levodopa) and were evaluated. Sixty-four percent of patients on levodopa and 34 percent of patients who received Requip completed the five-year study without supplemental levodopa therapy. The incidence of dyskinesias in the Requip and levodopa monotherapy groups was five percent and 36 percent, respectively. Of the patients who required supplemental levodopa, 20 percent of patients on Requip with supplemental levodopa developed dyskinesias compared to 46 percent of levodopa patients who required supplementation. Patients who received Requip had a significantly lower risk of developing any dyskinesias compared to patients who received levodopa. The mean dose of Requip at the end of the five-year study was 16.5mg/day. The mean dose of levodopa supplement for patients who received Requip was 427mg compared to 753mg for patients in the levodopa group who required supplementation "The study provides hope that Parkinson's disease patients treated with Requip alone or with low doses of adjunctive levodopa can live more active lives with less risk of developing dyskinesias," said Abraham Lieberman, M.D., Clinical Director for the National Parkinson Foundation. "The results strongly support the use of a second-generation dopamine agonist to treat early-stage Parkinson's disease." Requip was generally well tolerated. In this study, the adverse events were similar to those commonly associated with Parkinson's disease medications. They included nausea, somnolence, insomnia and Parkinsonism aggravated. All Parkinson's patients should be informed that fainting and low blood pressure may occur more frequently during initial treatment or with an increase in dose. Hallucinations can occur at any time during the course of treatment. Requip may potentiate the dopaminergic side effects of levodopa and may cause and/or exacerbate pre-existing dyskinesias. Requip is a second-generation dopamine agonist indicated for the treatment of the signs and symptoms of both early and advanced stages of Parkinson's disease and was approved by the U.S. Food and Drug Administration (FDA) in September 1997. A Progressive Neurodegenerative Disorder Parkinson's disease, which affects between 500,000 and one million Americans, is a chronic and progressive disorder that results from the death of nerve cells in a critical area of the brain called the substantia nigra. These nerve cells normally produce dopamine, a chemical messenger that plays an important role in motor movement control by transmitting signals between two areas of the brain. Dopamine depletion results in a patient's impaired ability to control motor movements. 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