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Sorry Grace in all the problems on the List I missed you letter. Usually I think 2 weeks without any response at all, is a sufficiently long trial for an antipsychotic drug although at times it can take longer. I think Kathrynne is quite right about the need to rule out an infection. I think the neurologist used the right drugs. I would however suggest clozapine as a trial since it has the most positive research written about it. It does have some risk- about 1-2% get aplastic anemia and therefore the drug needs to be monitored closely with weekly blood tests. You might want a psychopharmacologic oriented psychiatrist to see him since he probably has more experience with hallucinations and certainly with clozaril. Good luck, Charlie (retired psychiatrist) "Kathrynne Holden, MS,RD" wrote: > Dear Grace, > It's good you switched to another neuro, you deserve thoughtful answers > to a serious question like that of hallucinations. Is the new neuro a > specialist in Parkinson's disease? That's the best possible choice where > possible, because the source of hallucinations can be difficult to > pinpoint sometimes, and a PD specialists will have much more specific > experience in this area. > > A thought -- has the physician ruled out infection (including urinary > tract infection), dehydration, electrolyte imbalance, subdural hematoma, > or other possible cause of hallucination? This is not my area of > expertise, Charlie or Bob would be much better sources of information, > but I do know that dehydration and infections can be involved. > > It will be important that he receive plenty of fluids, 6-8 glasses a > day, and that he eat well. Nutrient loss and dehydration can worsen a > hallucinatory state. > > My very best regards to you and your husband, > Kathrynne > > Grace M McNamara wrote: > > > > Thank you for all the response. I am sorry I gave you the wrong idea. > > It is my husband who has PD. > > > > He was on the same medication since he was diagnosed, seven years ago, > > Four Sinemet 25/100 and two Eldepryl 5 mg. a day. When the hallucinations > > started and we were not getting answers from his neurologist we changed > > to another. He took him off the Eldepryl. It took about two weeks and > > he could not get out of the chair. He needed to be in a wheelchair. > > This doctor put him back on one Eldepryl a day. Movement better. We > > then started on anti psychotic pills, Olanzapine, Seroquel, Mellaril. > > Each separately for a few weeks with no results. Now we are taking > > Risperdal, with his Sinemet and Eldepryl. Have just increased the > > Risperdal to 4 mg. a day. Still hallucinating. Will stay on this for > > awhile because I believe we didn't give the other antipsychotics a > > chance. > > Sorry this is so long. We do appreciate your input. > > Grace > > -- > Kathrynne Holden, MS, RD > Medical nutrition therapy > Author: "Eat well, stay well with Parkinson's disease" > "Parkinson's disease: assessing and managing unique nutrition needs" > http://www.nutritionucanlivewith.com/ -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************