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However even movement disorder specialists may miss the diagnosis of Parkinson's disease, especially in the early phase. Typical features of Parkinson's disease may over time change with new, not to PD related characteristics. In addition, only post-mortem studies will confirm the diagnosis of PD. On the other hand, a dramatic response to levodopa (Sinemet, Madopar, Prolopa) may make the diagnosis of PD very likely.