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Thanks for the input about needing sinemet. At least I don't feel like I'm being unreasonable to ask for levodopa....although I agree minimal is best. Jeanette Fuhr ---------- From: Ronald F. Vetter <[log in to unmask]> To: [log in to unmask] Subject: Re: PERMAX as monotherapy in early PD Date: Thursday, August 05, 1999 8:19 AM Jeanette Fuhr wrote in part: <<I'm ready to say"Give me back the Sinemet so I can function more normally." Am I being impatient or not?>> i feel that your difficulties will require some levodopa. the Permax level should be perhaps retained - and try minimal levodopa. personally, i find the price of the generic carbidopa/levodopa better. the strictures against breaking CR tablets are not evidenced by the data. there is much variability in the absorption data of the Sinemet CR. i say (not an official or professional opinion, just what i have learned) try a small amount. it just may work well! the easiest schedule would be taking half of a 25/100 CR Sinemet three times daily - about 20 minutes before meals - or perhaps the first one-half upon awaking. -- Ron Vetter 1936, '84 PD dz [log in to unmask] http://www.ridgecrest.ca.us/~rfvetter