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Hans and other list family who replied to my post re:PERMAX as monotherapy, Thanks for all the concern and advice. I will call the nurses line at my neuero tomorrow AM and ask for a call back re: either increasing PERMAX and/or reintroducing sinemet. I'm hopeful that a change in meds will have me functioning as I was before when I was on sinemetcr/agonist/eldyprel. As Brian Collins stated, why suffer now when I could get hit by a truck and the martyrdom would have been for naught. Smiling now, Jeanette Fuhr :) ---------- From: Hans van der Genugten <[log in to unmask]> To: [log in to unmask] Subject: Re: PERMAX as monotherapy in early PD Date: Thursday, August 05, 1999 3:20 PM -----Oorspronkelijk bericht----- Van: Leo Fuhr <[log in to unmask]> Aan: [log in to unmask] <[log in to unmask]> Datum: donderdag 5 augustus 1999 14:43 Onderwerp: PERMAX as monotherapy in early PD Hi Jeanette, >> I have titrated up to .25mg 3xs daily with moderately fair results. << 3x0.25mg/day is a low dose. In general the effective dose for young onsets is around 3x0.50mg/day or more. So IMO you are simply undermedicated. I suggest you discuss with your neuro to gradually increase the Permax up to 3x0.50mg/day. If that doesnt help or keeps causing side-effects, THEN you might consider bringing in the Sinemet CR. Hans.