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Ronald F. Vetter wrote in part: <<personally, i find the price of the generic carbidopa/levodopa better.>> Generic carbidopa/levodopa is in fact less expensive than the brand name of Sinemet, however, some individuals will do better sticking with the brand name. By law, generics can have as much as 20% more or 25% less of the drug. Pharmacies do not necessarily obtain their generics from the same source each month, they usually go with the lowest bidder, so to speak. If the generic were consistently from the same source, <<i say (not an official or professional opinion, just what i have learned) try a small amount. it just may work well! the easiest schedule would be taking half of a 25/100 CR Sinemet three times daily >> The smaller does of Sinemet CR (25/100) cannot be broken without ruining the matrix of the tablet. The matrix is responsible for the controlled release action. Sinemet CR (25/100) is NOT a scored tablet and if you break it, you are in essence making it the same as plain Sinemet. For the sake of your safety, please ALWAYS check with your doctor before altering the way a medication is taken. Also, please try to remember, what works well with one person, may be harmful to the next. Sincerely, Bonnie Cunningham NPF