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Marty, et al... I too was prescribed Imipramine (plus oxybutin) to control PD-caused frequency and it not only did THAT (and well!) but I ended up with dry mouth (I sure drink a LOT more water than before) <rueful grin>, dry eyes, (I now single handedly support the eye-drops industry,) and oddly, the mild daily hay fever-like allergy I'd had since I was twelve years old COMPLETELY disappeared with the advent of these drugs. Strange to end up with an unexpected benefit out of a negative situation. Barb Mallut [log in to unmask] -----Original Message----- From: Marty Polonsky <[log in to unmask]> To: [log in to unmask] <[log in to unmask]> Date: Sunday, August 08, 1999 7:32 PM Subject: Re: Droooling >Hi y'all, >I know that this subject has been dealt with a some length in the past but I >don't think that what I have to share was specifically covered, and a nonPD >friend of mine has been bugging me to share this and decided that he was >right. I had a MAJOR problem with drooling after my second, bilateral >pallidotomy. I went through a couple of handkerchiefs per day and despite >this, I also ended up with ugly, ineradicable saliva stains just below the >collar on all my shirts By the way, this is one of the typical reactions to >bilateral pal's that accounts for neurosurgeons' reluctance to do them. >First, my neurosurgeon rx'd robinol, a mild tranquilizer with some tendency >to dry you out. This was of minimal help. I had better luck, although still >far from a solution to the problem by chewing gum--the bigger the wad the >better. Then, many months later, quite serendipitously, my urologist rx'd >imipramine (tofranil) for excessive urination. Imipramine is used primarily >as an anti--depressant but also as my urologist used it--to dry out my >system. Well, since around the time I started using the imipramine, my >drooling stopped and is no longer a major problem although I continue to >drool a little sometimes. This was accomplished with a minimal dose--40 mg >per day. I hesitate to pronounce this as a cure for 2 reasons: l. Trained >to do research in my training as a psychologist, it was drummed into my head >that correlation does not necessarily mean causation. 2. >I recognize that this might have been an idiosyncratic reaction by me that >will not necessarily occur in others. With these qualifiers in mind, I >offer this info to you and I hope that it helps somebody. >Marty Polonsky