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Brian wrote: these dopamine receptors have been holding-back dopamine all day - very gradually, but enough. So we arrive at the point where you have taken our last tablet, and some time later, the dopamine receptors decide that if they don't release the dopamine which they are holding, they are going to burst! Also, they cannot do their job if they are stuffed to the gills, so the dopamine is expelled in a great cloud and starts creating the dyskinesias which we know so well. Brian, If I do understand you well, you say diskinesia is allways caused by a surplus of dopamine. Wearing-off dyskinesia is im your model not caused by a diminishing level of dopamine but also by a surplus in disguise. You say wearing off dysk. can be prevented by not taking the last dose. If I skipp the last dose, the only effect is the wearing off dysk starts about 4 hours earlier. If I make my interdose times longer, I do have dyskinesia in every interdose time. That has happened years ago when I too thought dyskinesia meant to much dopamine and I tried to lower my intake. If the wearing off dysk. is there, I have the choice between waiting till it stops or postpone it by taking another dose of leva-dopa. To stabilise my leva-dopa level 24 hours a day is impossible, because of overdose dysk. which will destroy all the profit leva-dopa gives me. ( I do use now 3,75 mg each day (+12mg Requip). So your model fits for your symptoms and for the symptoms of most PWP's, but not for my symptoms and the symptoms of a minority of PWP's. Regards Ida -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]