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On Fri 13 Aug, Ida & Andre Kamphuis wrote: > Brian wrote: > > If I do understand you well, you say diskinesia is allways caused by a > surplus of dopamine. Wearing-off dyskinesia is im your model not caused by > a diminishing level of dopamine but also by a surplus in disguise. You say > wearing off dysk. can be prevented by not taking the last dose. If I skipp > the last dose, the only effect is the wearing off dysk starts about 4 > hours earlier. If I make my interdose times longer, I do have dyskinesia in > every interdose time. > That has happened years ago when I too thought dyskinesia meant to much > dopamine and I tried to lower my intake. If the wearing off dysk. is there, > I have the choice between waiting till it stops or postpone it by taking > another > dose of leva-dopa. To stabilise my leva-dopa level 24 hours a day is > impossible, because of overdose dysk. which will destroy all the profit > leva-dopa gives me. ( I do use now 3,75 mg each day (+12mg Requip). > So your model fits for your symptoms and for the symptoms of most PWP's, > but not for my symptoms and the symptoms of a minority of PWP's. > > Regards > Ida Hello Ida, There is no doubt that you are exceptionally sensitive to levadopa. Do I understand correctly that you take 3 tablets per day, of 75 mg each? That is interesting; do the 3 tablets actually give you the full 16 hour coverage? The contrast with my dose, which is also 75 mg but only lasts 2 hours is quite sharp. If you really are 'ON' most of the time, it suggests to me that there is a deficiency of whatever most people have to break down the dopamine ( COMT for example). The reason why I am so keen to promote the idea of the normal brain never exceeding a certain level of dopamine is that it makes way for such a simple concept to describe the Dyskinesias. It also, of course, explains why it gets more and more difficult to arrive at the correct dose of levadopa. I get so irritated when I read about another neuro stating that levadopa only lasts 6 to 8 years, after which, phrases like "response to treatment beginning to fluctuate" and "problems such as the on-off syndrome begin to occur." I ask every neuro that I meet how he thinks I still manage to use levadopa satisfactorily after 20 years (together with an agonist for the last 5 of course), and they have no answer. They need their best friend to tell them that just because the smallest tablet available is 50 mg that does not mean that life stops there and they can only use 50 or 100 mg . Sorry to have run on for so long. Regards, -- Brian Collins <[log in to unmask]>