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Mary, Zoloft is a good antidepressant for PWP. There are some warnings about mixing Zoloft and eldepryl (selegiline) but they don't contraindicate it but rather caution about its use. I have found it to be a safe and effective drug for many but not all PWP. The ones to watch out for primarily are the MAOI antidepressants which can affect blood pressure and should only be used with great caution. The tricyclics such as amitriptyline, imipramine etc. are good but tend to be harder to use without side effects and have largely been supplanted by the SSRI's like Zoloft, Good luck with whatever your doctor sees fit to prescribe. Charlie Mary Thompson wrote: > I would be thankful of some advice. I am going through a major loss of > confidence and feel very vulnarable brought on by a few problems with meds > not being effetive and aggrevated by the fact I'm due to travel to the > Sydney conference followed by my annual holiday with my husband and two > friends. I'm terrified of making a complete mess of things by getting down > and emotional if my meds don't work. You see my husband doesn't handle the > emotional side of the p.d. He's great at stepping in to help me but seems > completely lost when I lose it emotionally. I have had a change suggested > to my meds which I will try but an anti- depressant has also been > suggested. I can't remember which are the compatible ones. Can you please > help. I will try the achives but I just feel to tired to wade through reems > of info at present. Thanks in anticipation. Mary from Oz. -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************