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Guilford and Amgen Announce Start of Neuroimmunophilin Clinical Trials 08/04 05:49 THOUSAND OAKS, Calif.--(BUSINESS WIRE)--Aug. 4, 1999--Guilford Pharmaceuticals Inc. (Nasdaq: GLFD) and Amgen (Nasdaq: AMGN) Wednesday announced that the companies have initiated the first clinical testing of a class of compounds known as neuroimmunophilins. The initial study is a phase 1 safety, tolerability and pharmacokinetic study in healthy subjects and is being conducted in Europe. The initial disease target is Parkinson's disease. "We have reached an important milestone in the development of the neuroimmunophilins. We will undoubtedly learn a great deal about neuroimmunophilins over the next few months, and, assuming a successful outcome of the phase 1 clinical program, we look forward to the first clinical trials in patients with Parkinson's disease," said Dr. Craig R. Smith, president and chief executive officer of Guilford. In 1997, Amgen licensed from Guilford worldwide rights for the neuroimmunophilins, a novel class of small molecule neurotrophic agents that may represent a new approach in the treatment of neurodegenerative disorders. In preclinical studies, including models of Parkinson's disease, neuroimmunophilins demonstrated potential to promote nerve regeneration and repair. "We are pleased to be able to advance Amgen's second small molecule product candidate into clinical testing," said Gordon Binder, Amgen's chairman and chief executive officer. "This represents our growing commitment to the field of small molecule drug development. More importantly, it is a further effort to advance the needed treatment of patients suffering from Parkinson's disease." Amgen is a global biotechnology company that discovers, develops, manufactures and markets cost-effective human therapeutics based on advances in cellular and molecular biology. Guilford Pharmaceuticals is a biopharmaceutical company engaged in the development of polymer-based therapeutics for cancer, and novel products for the diagnosis and treatment of neurological diseases, including Parkinson's disease, Alzheimer's disease, stroke, severe head trauma, spinal cord injuries, multiple sclerosis and peripheral neuropathies. EDITOR'S NOTE: An electronic version of this news release may be accessed via Amgen's Web site at www.Amgen.com. Visit the Corporate Center and click on Amgen News. Journalists and media representatives may sign up to receive all news releases electronically at time of announcement by filling out a short form in the Amgen News section of the Web site. AltaVista.com| About AltaVista |Help| Feedback| Advertising Info | Add a Page Disclaimer | Privacy | Copyright | International | Set your Preferences Content Integrated at TIBCO.net using TIB/ActiveEnterprise Software. Copyright 1999 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. ----- Original Message ----- From: Pennie Farnham <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, August 10, 1999 5:41 PM Subject: Amgen studies > Was looking up the the Amgen studies and could not find information about > the new drug neuroimmunopilins. Can someone help. > > Pennie Caregiver to Terry > > > ______________________________________________________ > Get Your Private, Free Email at http://www.hotmail.com >