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At 20:19 13-8-99 +0100, Brian Collins wrote: >On Fri 13 Aug, Ida & Andre Kamphuis wrote: >> Brian wrote: Do I understand correctly that you take 3 tablets per day, of >75 mg each? That is interesting; do the 3 tablets actually give you the >full 16 hour coverage? The contrast with my dose, which is also 75 mg >but only lasts 2 hours is quite sharp. Brian That is nearly correct. I wrote that I use 375 mg.each day That is at 10a.m. at 1.30 p.m. and at 5 p.m 100mg sin.CR plus 0,25 mgr sin.reg., which makes a total of 3.75 mgr. I can't take smaller doses, because doing so the only effect is that I get dyskinesia as long as the meds are active or wearing off. I am not the full 16 hours on. In the morning I have the profit of sleep .From about 10.p.m til 11p.m.or 11.30p.m. I have my dyskinesia hour. The time after that I have an off-time as long as I stay awake, but that is not very bad, as long as I don't want to do too much. To be "real" off I need a few days without sinemet. My Neuro says I s should not try that. In my experience all patients who suffer from wearing off dyskinesia use only very low doses sinemet I wonder whether total body weight has any unfluence on the amount of sinemet one needs. For some meds this is true, but the topic is in general rather underexposed in ppharmacology. Ida -------------------------------------------------------------- Vriendelijke Groeten / Kind regards, Ida Kamphuis mailto: [log in to unmask]