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Glen Pagliaccio wrote in part: <<Realistically, is it possible for him to regain his mobility? Also, my father-in-law, (also a PWP of eight years) has in the last 4 weeks been exhibiting "reduced cognitive abilities", often rambling and speaking irrationally, and often not knowing where he is. This has happened suddenly, not progressively. He is due to see his neurologist in the next few days. His medication is Sinemet and Permax. I have heard that Permax can have this effect on some people. Is this correct?? and could simply changing his medication quicly correct this? With two PWP in our immediate family suddenly showing these symptoms, I suppose I am looking for some reassurance and hope.>> opinions, i would say that such abrupt changes for the worse are not so common. however, the effect on attitude could be devastating. if there have been strong emotional difficulties, help to overcome the depressing event could result in regaining mobility. has there been psychological support loss? is their good caregiving available to each? hope this helps some. please be assertive in seeking qualified help for them. -- Ron Vetter 1936, '84 PD dz mailto:[log in to unmask] http://www.ridgecrest.ca.us/~rfvetter