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My mother takes Sinemet in liquid form 20-30 minutes before eating her meals. That has made a tremendous difference. Of course, you may want to see what others (who use the CR version) have to say. Teresa, Daughter of Mama (57/43/38) -----Original Message----- From: Parkinson's Information Exchange [mailto:[log in to unmask]]On Behalf Of Cynthia Shook Sent: Tuesday, August 17, 1999 11:44 AM To: [log in to unmask] Subject: Medication Hi list.... OK, I know you have helped me before but Mom is argueing with me about grandma's medication. Mom knows it needs to be taken on a pretty empty stomach but she is really scrambling things. Scenerio: Mom feeds Grandma, waits 2 hours then gives Siminet CR. Grandma takes this 3 times day. Mom said this is a hassle. I told mom she needs to give it about 30 minutes to an hour before Grandma eats so it will get into the system and there is not such a long time before getting something in the stomach and it won't upset. We are also working on a low-mid protein diet. Mom said that my way would be easier buuuuut she wants advice from all of you that have been dealing with PD longer. Thanks again for your help. Cindy _______________________________________________________________ Get Free Email and Do More On The Web. Visit http://www.msn.com