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Bill, You certainly have a family history which gives one pause. The fact that three members of your family have PD makes it likely that you have a familial form of PD. I believe Graves Disease can also run in families but there is no family relationship between the 2 that have it. Depression clearly runs in families and your wife's side of the family seems to have it in spades. Your daughter has probably one illness with 3 manifestations. The primary illness is probably depression with the variations of depression showing themselves as substance abuse and eating disorder. I wouldn't venture a guess as to what comes next Bill. You've had a rough time of it but one can hope things get better. They can't get much worse... Charlie William Harshaw wrote: > To: The P.I.E.N. List > > >From Bill Harshaw > > Subject: A Question of Genetics > > 1. I have Parkinson's Disease > > 2. My mother and maternal grandmother each had Parkinson's Disease > > 3. My father's sister was likely schizophrenic. The only description we > ever had of her medical condition was that he had ‘nerves'. This woman was > born in 1899. > > 4. My wife's aunt (a fraternal twin of her mother) had both Graves' disease > and Multiple Sclerosis. > > 5. My wife's father had both Graves' Disease and Ankylosing Spondylytis > > 6. Our son has ulcerative colitis > > 7. My wife's mother is subject to depression as is my wife and two of three > of her siblings and several of their offspring are subject to depression as > well > > 8. Our daughter has an eating disorder, is subject to depression and is a > substance abuser > > Question Does anyone know what is likely to happen next? -- ****************************************************************************************** Charles T. Meyer, M.D. Middleton (Madison), Wisconsin [log in to unmask] ******************************************************************************************