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hi all At 21:10 1999/08/31 -0700, ervin and i wrote: >Janet, by all means answer via the list, I'm anxiously awaiting. I failed >to mention the same Neuro four months ago prescribed Mirapex which I tried >for about six weeks but failed to have any favorable results. Negative >results were swollen ankles and fatigue attacks. Thank again. >[log in to unmask] > >> i have lots to say if this is your very first prescription for sinemet!! >> would you mind if i answered your message via the list? >> there are a lot of newbies on board who might be interested >> >>>Janet, have been reading your discussion on sinement. I just returned from >>>my Neuro today and he prescribed 25/100 three times a day. This will be my >>>first experiment with the drug. Would you have any input or advice.? I >>>have been diagnosed for about three years. Best wishes >>>[log in to unmask] the biggest concern for most people starting on sinemet is the potential for nausea the best way around this and also the best way to start any new med adjusting our brain chemistry is "low and slow" e.g. when i started sinemet i took 1/2 tab per day for a few days or a week and then bumped it up by another 1/2 tab per day for a few days or a week etc etc very slowly till i saw some symptomatic relief i still did have stomach trouble and had to have something to eat whenever i took sinemet to avoid nausea and gastric pain [this is advice aimed at newbies to sinemet and pd] [medium-timers probably need to take sinemet before meals to avoid food interfering with the absorption of the sinemet] i hope your neuro discussed this with you jumping into 300 mg per day all at once seems to me to be a tad insensitive to a very common problem and i'm wondering if a similar approach might have been a contributing factor to your lack of success with mirapex? i don't want to jump the gun here but we've seen a lot of med management styles similar to try this! oops that didn't work here, try this instead! please read joe's story on my website in the pienet/words section if you haven't already our brains are like finely tuned maseratis they need adjusting with finesse not with monkey wrenches! tell us a bit more about your neuro - a pd specialist? and about your symptoms? janet ps after i titrated up to an effective dosage level [it took three weeks] i was on top of the world my symptoms were gone gone gone that's why levodopa is the gold standard for pd things aren't quite as simple as that now but sinemet is still a miracle in my book janet paterson 52 now / 41 dx / 37 onset po box 171, almonte, ontario, canada, K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> parkinsn topics: fun list news nonpd pmid qt technews udall <mailto:[log in to unmask]>