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To: Michel Margosis What sets Parkinson's Disease apart from the other chronic conditions that plague medical science? 1. The number of young onset patients is increasing, i.e., the demographics are changing; 2. There are a number of neurosurgical procedures which have proven track records in easing synptoms, i.e. pallidotomy and DBS. While I haven't seen any good data on the cost/benefit analysis, my own medication bill is down by $12,000 annually. I would estimate a discounted cash flow payback in about five years. If Mr Gates wants to do some real good for PWPs he could: 1. Fund the education of functional neurosurgeons 2. Set up functional neurosurgery centres, complete with infrastructure, to perform the operations. It would cost about $5 million per centre