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hi all ervin asked: >------------------------------------------------------------------- >From: "ERVIN J MCCARTHY" <[log in to unmask]> >To: "janet paterson" <[log in to unmask]> >Subject: Confused >Date: Wed, 1 Sep 1999 19:12:06 -0700 > >Janet, being new to Sinement may be you can clarify something for me. >I often see reference to the drug in different ways. Cardopa/levadopa >and many times the names are reversed. Does this have a purpose? >Sometimes I see numbers reversed such as 25/100, or 100/25, >10/100 or 100/10. Are they mistakes in the numbers or am I just >being confused? Thanks again >------------------------------------------------------------------- and the archives answered: >------------------------------------------------------------------- >>> Posting number 29060, dated 11 Aug 1997 11:30:43 Date: Mon, 11 Aug 1997 11:30:43 -0400 From: janet paterson Subject: Re: SINEMET 25/100 switched to 10/100 hi to ivan and joanna; the best med for dealing with pd symptoms is levodopa combined with an extracerebral decarboxylase inhibitor 'Sinemet' is available in the usa and combines levodopa with carbidopa 'Madopar' is available in europe and combines levodopa with benseraside sinemet is available in different proportions: 25/100 = 25mg carbidopa/100mg levopdopa 10/100 = 10mg carbidopa/100mg levodopa we all know that the levodopa is intended to replace the lost dopamine in our brains the carbidopa is intended to reduce the nausea and other side effects that levodopa will cause if taken by itself the amount of levodopa that we require depends on our personal sistuation re symptoms the amount of carbidopa recommended is 75 mg per day minimum: the Young Parkinson's Handbook advises a range of daily dosage of 75-150 mg carbidopa the reason sinemet is offered in different proportions is to allow adjustment and fine tuning of your daily intake of both levodopa and carbidopa for example several years ago, when i was suffering ongoing stomach problems my sinemet intake was 5 x 10/100 daily: carbidopa = 5 x 10 = 50 mg daily levodopa = 5 x 100 = 500 mg daily my pharmacist, and later my g.p., advised that my carbidopa level was too low and was probably adding to the nausea situation: so my sinemet was adjusted to 2 x 25/100 and 3 x 10/100 daily: carbidopa = 25+25+10+10+10 = 80 mg daily levodopa = 5 x 100 = 500 mg daily at the moment my sinemet intake is 9 x 10/100 daily: carbidopa = 9 x 10 = 90 mg daily levodopa = 9 x 100 = 900 mg daily if i were to add mirapex to my 'chemical soup' and if i achieved a 25% reduction in my need for levodopa: the sinemet might change to 1 x 25/100 and 6 x 10/100 daily: carbidopa = 25+10+10+10+10+10+10 = 85 mg daily levodopa = 7 x 100 = 700 mg daily i hope this helps the more we know about our meds the better knowledge is power with love from your syber-sis janet >------------------------------------------------------------------- janet paterson 52 now / 41 dx / 37 onset 613 256 8340 po box 171 almonte ontario canada K0A 1A0 a new voice: <http://www.geocities.com/SoHo/Village/6263/> <[log in to unmask]>