I have been lurking on the list for some time. My Husband a retired MD has been a member of the list for the same time. I am a PWP aged 63 who was diagnosed approx. 7 yrs ago. I am well controlled; I take Sinemet CR 100mg x 4 and Permax 250 x 3 My problem is with my bladder. Frequency has been a slight problem all of my adult life, but it is getting much worse - frequency, urgency (no incontinence) every 1/2 hour. I am supposed to be going on holidays at the end of the month and I'm very concerned about coping. I have been to a couple of Urologists. Here is a list of treatments I've tried: 1) Fluoroscopic exam. of bladder indicating a small sensitive bladder. 2) Stretching under general anaesthetic - wonderful result which lasted one week. 3) Ditropan 2.5 mg x 3 - slight improvement. 4) Tolteradine (new drug trial) - no use. 5) Phsiotherapist - electrodes to lower back - no use. A final suggestion has been "Interstim Continence Control" Therapy. An implant which stimulates nerves in the sacrum. This sounds very drastic but apparently has 65% success rate. Yesterday I took valium which seemed to help. Has anyone any advice that can help me. Veronica.