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My husband was diagnosed 4 months ago. He went from 2 (25/100) Sinamets a day to 4 to 6 in a matter of 2 months. Went for a second opinion and this neuro put him on 4 (25/250) Sinamets per day. At this same appointment my husband complained of pain in his leg and neuro insisted there is no pain with PD. We asked about the connection of the pain to the Sinemet as the pain increased as the Sinemet increased. He insisted no connection. My husband went onto the 4 (25/250) per day and the pain and dyskinesias (which the neuro insisted were not dyskinesias) became intolerable - pain from hip to foot and couldn't sleep at night. After 7 days of this he went back to 4 of the 25/100s for one day, three the next, two the next and one the next until he was taking nothing. Pain and dyskinesias disappeared. This was last week. He has an appointment with the neuro this Friday and we are going to try to firmly, but politely tell him he is dead wrong. Sure, there may not be pain with PD, but there sure is pain associated with the wrong dose of Sinemet. We have an appointment in Oct. with yet a third neuro - this one is supposed to know his stuff when it comes to PD - we'll see. The first two have been a huge disappointment! Good luck. Jackie -----Original Message----- From: Earnie & Barbara Knight <[log in to unmask]> Date: Wednesday, September 01, 1999 7:05 AM Subject: Re: nausea/Sinemet/JanandErw >Hi, > >I'm a newbie to the list and to PD. I've been on Sinemet for about three >months. I was supposed to be on 25/100 3x a day, but the pharmacy made a >mistake and filled the prescription with 25/250! I was really nauseated >after taking the pills. (Ate soda crackers too, which helped somewhat.) I >didn't discover the pharmacy error until I went back for a refill, and got >the 25/100's! > >Taking the right strength of Sinemet has really helped. I feel almost >normal (whatever normal is, lol) I've also been taking Eldepryl now for >about a month. I'm able to walk better, except I've been having problems >with pain in my left leg from my hip to my ankle. Some nights I can't sleep >because I can't get comfortable. Has anyone else experienced this? My neuro >said after he resolved the other problems he'd deal with this. He thought >the meds might help, and they have to some degree. > >I have questions about diet too. Nothing was said about the problems of >eating protein with Sinemet but I did hear about this from another PD >friend. Wondering if there's something I should know also about Eldepryl. > >Appreciate any help, >Barbara 61/61/? > > > > >At 11:36 PM 8/31/99 EDT, you wrote: >> Hi, All ! >>Janet and Erwin have been discussing the side effect,nausea,at the >>introduction of Sinemet. >>It is my understanding that the carbadopa part of Sinemet is what keeps the >>levodopa from producing systemic side effects, such as nausea. >>Back in1984 when I first started Sinemet 10/100, I had full-blown nausea >>after each dose. To ease the nausea I devourred afew soda crackers following >>the med ....It was some relief. >>When I finally advanced to 25/100 Sinemet I had no more nausea. >> >>That's just my experience..I'm not a professional....Ask your doctor ! >> [log in to unmask] )Mary Manfredi) fourscore plus two/dx 15 >> >> >