Thanks for all the responses onSinement. Janet, in response your questions my neuro is a motion disorder specialist. He also put me on slow start with 1/2 of 25/100 just at breakfast for the first week, breakfast and lunch for the second week, breakfast lunch and dinner for the third week and a full 25/100 in the fourth week. Thanks for the caution on nausea. Hope this does the trick. [log in to unmask] ----- Original Message ----- From: janet paterson <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, August 31, 1999 7:16 PM Subject: Re: ervin starts on sinemet > hi all > > At 21:10 1999/08/31 -0700, ervin and i wrote: > >Janet, by all means answer via the list, I'm anxiously awaiting. I failed > >to mention the same Neuro four months ago prescribed Mirapex which I tried > >for about six weeks but failed to have any favorable results. Negative > >results were swollen ankles and fatigue attacks. Thank again. > >[log in to unmask] > > > >> i have lots to say if this is your very first prescription for sinemet!! > >> would you mind if i answered your message via the list? > >> there are a lot of newbies on board who might be interested > >> > >>>Janet, have been reading your discussion on sinement. I just returned from > >>>my Neuro today and he prescribed 25/100 three times a day. This will be my > >>>first experiment with the drug. Would you have any input or advice.? I > >>>have been diagnosed for about three years. Best wishes > >>>[log in to unmask] > > the biggest concern for most people > starting on sinemet is the potential for nausea > > the best way around this > and also the best way to start any new med adjusting our brain chemistry > is "low and slow" > > e.g. when i started sinemet > i took 1/2 tab per day for a few days or a week > and then bumped it up by another 1/2 tab per day for a few days or a week > etc etc very slowly till i saw some symptomatic relief > > i still did have stomach trouble and had to have something to eat > whenever i took sinemet to avoid nausea and gastric pain > > [this is advice aimed at newbies to sinemet and pd] > [medium-timers probably need to take sinemet before meals to avoid > food interfering with the absorption of the sinemet] > > i hope your neuro discussed this with you > jumping into 300 mg per day all at once seems to me > to be a tad insensitive to a very common problem > > and i'm wondering if a similar approach > might have been a contributing factor to your lack of success with mirapex? > > i don't want to jump the gun here > but we've seen a lot of med management styles similar to > try this! > oops that didn't work > here, try this instead! > > please read joe's story on my website in the pienet/words section > if you haven't already > > our brains are like finely tuned maseratis > they need adjusting with finesse > not with monkey wrenches! > > tell us a bit more about your neuro - a pd specialist? > and about your symptoms? > > > janet > > > ps > after i titrated up to an effective dosage level > [it took three weeks] > i was on top of the world > my symptoms were gone gone gone > that's why levodopa is the gold standard for pd > > things aren't quite as simple as that now > but sinemet is still a miracle in my book > > janet paterson > 52 now / 41 dx / 37 onset > po box 171, almonte, ontario, canada, K0A 1A0 > a new voice: <http://www.geocities.com/SoHo/Village/6263/> > parkinsn topics: fun list news nonpd pmid qt technews udall > <mailto:[log in to unmask]>