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Hi Guys: Just want to throw my 2 cents in and address Joe's last point. Agree it is always better to err on the side of caution when dealing with new drugs because, as we know, many side-effects don't become evident until larger groups of consumers begin taking the product, for example, sexual dysfunction and the SSRIs. Carole H. --- "J. R. Bruman" <[log in to unmask]> wrote: > Sorry, Brian- your first statement, that U.S. > "medical authorities" > (FDA) don't allow two prescription applications for > a single drug is > incorrect. Before the advent of cabergoline, the > drug of choice was our > old friend bromocriptine (Parlodel), whose > (FDA-approved) Product > Description in the Physicians' Desk Reference, p. > 2072, Indications, > includes treatment for BOTH hyperprolactinemia and > Parkinson's Disease. > > Hyperprolactinemia occurs in men as well as women, > when it may follow > atrophy or absence of the anterior pituitary, a > common experience that > accompanies aging. Prolactin from the pituitary, a > bean-size gland at > the base of the brain, is held in check by dopamine > that comes not from > the substantia nigra but from the thalamus. And a > dopamine agonist such > as bromocriptine or cabergoline works equally well, > just as it does in > Parkinson's disease. > > Because cabergoline seems to have much fewer nasty > side effects than > bromocriptine, and especially since its half-life of > 65 hours permits > Parkinson's sufferers to sleep all night through, > some naturally were > disappointed when it didn't become available here, > and asked why not. > I've personally been given the reason I cited, by > seminar speakers in > a position to know. > > Regarding my allusion to pramipexole (Mirapex) > turning out to be less > than a miracle drug, it certainly seems to be an > improvement over its > two older rivals, bromocriptine and pergolide > (Permax). But you never > know, and the recent reports of sudden unpredictable > blackouts caused > by Mirapex might be a case in point. Cheers, > Joe > -- > J. R. Bruman (818) 789-3694 > 3527 Cody Road > Sherman Oaks, CA 91403-5013 > __________________________________________________ Do You Yahoo!? Bid and sell for free at http://auctions.yahoo.com