Friends-- a neighbor gave me an article from a magazine called "American Health" (july-August '99) ca;;ed "Nature's Newest Anti-depressant", with emphasis on depression, but also claiming help for arthritis, fybromyalgia, and PD. It is from an interview with a psychiatrist, Dr. Richard Brown, Associate Professor of Clinical Psychiatry at Columbia U. College of Physicians & Surgeons--sounds pretty reputable. SAM-e is the short name for S-adenosylmethionine, "a popular depression treatment in Europe, now on the shelves of your local drugstores". Dr. Brown uses it selectively with his patients and says it can be added to or substotuted for SSRI type antidepressants like Prozac, with fewer side effects, especially in mild depression, cautioning not to use it in bipolar type. SAM-e is said to be " a chemical in the body that's central to at least 35 essential metabolic reactions. It eases depression by RAISING THE BRAIN'S LEVEL OF SEROTONINS AND DOPAMINE...AND STABILIZING THE NOREPINEPHRINE TRANSMITTER SYSTEM so it can send chemical messages effectively." (emphasis mine ) Does this sound reasonable/correct to the experts onlist? Has anyone (hello, over in Europe?) used or heard of this ? I wonder if it is used, as St. John's Wort is, for relieving depression by some PWPs?I told my neighbor, who was just trying to be helpful, that I'd check it out---on the web I did an ALtaVista search and came up with LOTS of items, mostly re: depression, arthritis, and where to buy it at lowest price--nothing re: PD. (It is not cheap, of course!) Comments are welcome. Camilla Flintermann, CG for Peter 81/70/55 Oxford, Ohio http://www.newcountry.nu/pd/members/camilla/one.htm <[log in to unmask]> "Ask me about the CARE list for Caregivers of Parkinsonians ! "