Ervin wrote--- >I asked if they should be taken at meals or on empty stomach and they said "it >didn't make a difference." SNIPPED Any comments would be appreciated by anyone >experienced with Sinement. >[log in to unmask] Hi Ervin--I'm not Brian, but I do know that it can/does make a difference when you take the regular Sinemet (not CR). Because dopamine and protein compete, and because Sinemet needs to get out of the stomach into the small intestine to be absorbed, you should take it a half hour before or an hour or hour and a half after eating, ideally, to get the best effect from the meds. As you are newly diagnosed, the protein competition is not so important, but you should be aware of it later. With the CR form, as it dissolves slowly over time, it's not so important. If SInemet causes nausea at first, try taking it with a few crackers....that should go away after a while, and not everyone gets nauseated. The National Parkinson Foundation has a free booklet , Nutrition Matters, one of their excellent series--you can get a copy of any or all of them by calling 1-800-327-4545. Camilla Flintermann, CG for Peter 81/70/55 Oxford, Ohio http://www.newcountry.nu/pd/members/camilla/one.htm <[log in to unmask]> "Ask me about the CARE list for Caregivers of Parkinsonians ! "