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Dear Janet, I'm so sorry not to have responded to your message. I've only just found it while searching through the list of E-mails for something else. > what dosage sinemet are you on? > what is your daily total med intake? > are you taking any pd meds other than sinemet? > The doseage sinemet I am on - Sin CR (50mg carbidopa + 200mg levadopa ). I have 4 of these per day, I also have 2 Sinemet (carrbidopa 25 + levidopa 100). these I take to bridge the gaps when the Sinemet CR runs out. So my day starts at 7.15am. when I take 2 Sin CR. At about 11.30 I take just halfa of a Sinemet and at 12.00 I take one Sinemet CR. This sees me through until I 4.00pm when I take the other half of the sinemet tablet. At 5.00 I take the fourth Sinemet CR tablet and about 9 .00 pm. I take the second Sinemet tablet. I don't have any other medication for my parkinsons. I do have medication for high blood pressure - Atenolol 50 mg - one tablet per day - which I have been treated for since I was about 45 yrs old. > > if you get 'mushy brain' symptoms when you forget to take a pilld > or have too much protein, you can bet your booties > that the 'horrid feelings' are a symptom > of the dopamine shortage in your brain > > i don't think it can correctly be labelled 'addiction' > are diabetics 'addicted' to insulin? > > the simplest way to know if you are taking too much levodopa > is if you develop dyskinesia - uncontrolled movement or 'twitchiness' > > if you haven't seen that particular med side effect > then you are still in the 'honeymoon' stage with sinemet > so enjoy! > I have noticed that since I have been put on the Sin.CR tablets I have been quite twitchy at times . during the afternoon in particular. But if I do not have the med. about mid-day then I develop tremor, "mushy brain" etc. It all seems to be finely balanced and difficult to get just right. Perhaps I should explain that my younger son Richard - who has set me up with his second-best computer and a modem - visits me at the week-ends and is teaching me how to use it. Usually I wait for his visit to sort out any difficulties I get into. Message for Chris Campbell. Hi! Thanks for the tip about sorting the mail by subject. It was very helpful. Apologies to you, too, for not replying earlier. Mary.