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Mr. Adams: Benadryl may alter the chemical balance in the brain between dopamine and acetylcholine, thus increasing Parkinson symptoms. In Parkinson's, we need to maintain a delicate balance between these two neurotransmitters to offset Parkinson symptoms. As a class, Benadryl falls within the category of drugs called anticholinergics. Currently, Artane and Cogentin are the most commonly used anticholinergics for Parkinson's. Although Benadryl does help some patients with muscle cramps, I recommend Parkinson patients talk with their neurologist before they take Benadryl. Also, side effects of Benadryl limit its use in Parkinson's. These include dry mouth, constipation, dry eyes, blurred vision, urinary retention and confusion. Dominic Marchese, RPh. Athena Rx Home Pharmacy 1-800-5-ATHENA Message ----- From: CHET ADAMS <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, September 14, 1999 7:07 PM Subject: Muscle cramps/Benadryl > A recent posting suggested use of Benadryl to relieve muscle cramps. > Does anyone have knowledge of contraindications of taking Benedryl with > anti-parkinson medications, sedatives and/or anti-depressants ??? > thanks... >