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I can't answer for Merlin, but I can tell you I had the same problem with "very drowsy and swollen ankles". Over a four month period I took meds to reduce swellling,didn't work. Had a MRI scan, showed only minor arthritis and tendentious, Dr. put ankle in a cast for one month, didn't help, Stopped taking Mirapex (1.5mg per day) and two days later swelling and pain in ankle were gone, that was about three weeks ago, My tremors are a little worse but I'll take the swap. I think sinemet is the only med. that is time proven to be the most effective for the most people. I would think long and hard before giving it up, but PD and the meds effect us all differently. ERVIN J MCCARTHY wrote: > Merlin, I have been diagnosed for about two years and have tried Mirapex as > my first drug and found it to make me very drowsy and swallowen ankles. I > discontinued Mirapex about two months ago. I have just started Sinemet for > about three weeks now. I feel at this point my tremors have increased. Is > this possible? I am beginning to gather from the list that it is a goal to > get off of sinemet. Is that true? It appears to be in your case. Have you > had no adverse reactions to Mirapex? Any information would be helpful. > Thank you > [log in to unmask] > ----- Original Message ----- > From: Merlin H Brown <[log in to unmask]> > To: <[log in to unmask]> > Sent: Sunday, September 19, 1999 7:24 PM > Subject: Re: Dyskinesias > > judith, i was taking a 50/200cr at the beginning of the day. then > sometimes i took 25/100 regular sinemet in the afternoon. my wife says i > was just starting to exhibit some dyskenesia but i hadn't noticed it. my > biggest problem with resting tremor on my right side was when i was under > stress or got very cold. i am now retired and have sold my business so > the stress is considerably less. yes, i try to minimize my exposure to > extreme temperatures. i have been taking mirapex for about two years and > have had no sinemet in that time. the dyskenesia completely disappeared. > i'm saving the sinemet for a rainy day! lol > > murph brown 57/9 > > On Sun, 19 Sep 1999 21:37:11 -0400 judith richards <[log in to unmask]> > writes: > > Merlin H Brown wrote > > > > >nina i take the following > > >1mg mirapex 3x/day, 5mg selegline 2x/day, 100 mg symetrel 2x/d > > >by phasing in the mirapex, I was able to completely eliminate the > > >sinemet. > > >no dyskinesia. > > >The preceding provided for what it's worth > > >murph brown 57/9 > > > > Murph, > > Interesting. How much Sinemet were you taking, how often and for > > how > > long, and did you have any dyskinesia before eliminating Sinemet? > > Thanks, > > > > Judith > > -- > > Judith Richards, London, Ontario, Canada > > [log in to unmask] > > ^^^^ > > \ / > > \ | / Today's Research > > \\ | // ...Tomorrow's Cure > > \ | / > > \|/ > > `````