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At a Parkinson's seminar I attended a former pharmacist who has Parkinson's said no one with PD should take Benadryl. Can't tell you just what the problem was, but something to do with the chemical reaction it caused in the brain. CHET ADAMS wrote: > A recent posting suggested use of Benadryl to relieve muscle cramps. > Does anyone have knowledge of contraindications of taking Benedryl with > anti-parkinson medications, sedatives and/or anti-depressants ??? > thanks...