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Bill, Nancy withdrew from Mirapex and returned to Permax without any proplems. She did it cold turkey and had no problems. The Mirapex didn't seem to have any advantage over the Permax for her. At the time she was experiencing a radical weight loss and we were trying to ween her from all new meds and get her back on the old meds to see if that would stop the weight loss. It did stop the weight loss but we never did figure out why she had the loss occurred. Bob Martone -----Original Message----- From: Parkinson's Information Exchange [mailto:[log in to unmask]]On Behalf Of Bill Bell Sent: Thursday, September 16, 1999 10:46 PM To: [log in to unmask] Subject: Switching from Mirapex to Permax. Greetings, A friend called today to ask if I would pose a question to my braintrust, the List. Here goes. His doctor is suggesting he switch from Mirapex to Permax. The doctor also said that both can be taken together as you bring the Permax up in dose, and bring the dose of Mirapex down. Has any of you been thru the same process? Did you stop the Mirapex gradually then began the introduction of the Permax? Any insights would be greatly appreciated. Thanks in advance and best to all. Warm regards Bill Bill Bell Executive Director Northwest Parkinson's Foundation 425-746-5556 / [log in to unmask] http://www.nwpf.org