> Bill - I am taking both Mirapex and Permax. I was introduced to Permax first (as a supplement to the Sinemet, and instead of an increase in Sinemet dosage). I had been suffering from restless legs at night and the Permax was very helpful. I titrated up to 1/2 a tablet 3 times a day. About 18 months later, the leg problem rerturned and this time one Mirapex at bedtime was added to the regimen. 3 months ago, when it looked like I needed more of something the dosage was rearranged and currently I take: Sinemet (25/100-1/2 tab) and Permax (.5 mg) together 4X/day Mirapex (.25 mg) at bedtime Eldepryl (5 mg) in A.M. Everything looks good for now Nancy Shlaes deGrazia