Hi...can anyone tell me what is likely going on here? A problem which has been going on now for many, many months has gotton much worse on occasion recently. I need practice in describing it and feedback from my list cyber-family in preparation for contacting my MDS tomorrow. I first noticed internal rigidity in my throat at nite upon going to bed. It usually was/is relieved by morning. Adjustments I made were to sleep with my head and torso raised. I think my MDS increased my Elavil in response to my report of this symptom. On a few nites it was so painful that I got up and played Solitaire games on my computer. Recently (about last two weeks), I have started having incidences during the day whereby I feel my throat start to constrict, as it did yesterdauy afternoon and to a lesser degree around 11:15 a.m. today. I find it quite alarming. I think in most of these daytime incidences, it occurs after my usual dose of meds while they are kicking in. But I have audible breathing at other times as well. (perhaps before I take meds) Also, I have had incidents of worse dyskinesias. The med schedule I have been following for some time is as follows: 6:30 am arise 7:00 1 xanax (0.25 mg) 7:30 1 mirapex (0.25) 8 2 Sinemets (25/100) 1 Tasmar (100 mg) 11 to 12:30 2 mirapex 11 to 1 2 sinemets 4-5 1 xanax 5 to 6 2 mirapexs 5:30 to 6:30 2 sinemets 1 Tasmar 10 pm 3 Elavils 25 mg I look forward to your input and/or questions. Thanks. Regards, Barb B-K -- Barbara Blake-Krebs [log in to unmask]