Print

---

Joe, Dominic and Chris,
    Thank you for your quick replies.

Dominic, you wrote:
>>...Will the side effect profile resemble tolcapone and
also have the possibility of liver problems?  A study of 700 patients
who
had received entacapone for 6 to 12 months had no evidence of abnormal
liver
function tests as a result of entacapone administration.  Until the
product
is approved, it is unknown whether liver function tests will be required
and
monitored by the FDA.<<

    Thank you for this clarification. I asked a neurologist/speaker the
same question and his response was that liver monitoring would not be
necessary. I have also read this elsewhere. That's why I was surprised
to read that liver function tests might still be necessary.

Judith
--
Judith Richards, London, Ontario, Canada
[log in to unmask]
                          ^^^^
                           \ /
                         \  |  /   Today’s Research
                         \\ | //         ...Tomorrow’s Cure
                          \ | /
                           \|/
                          `````


-----Original Message-----
From: Chris van der Linden <[log in to unmask]>
To: [log in to unmask] <[log in to unmask]>
Date: Saturday, September 18, 1999 3:37 PM
Subject: Re: Entacapone & liver monitoring


>Liver monitoring for entacapone not necessary, at least not in Europe
>
>tolcapone, as you probably all know, has been taken off the market
because
>of incidental cases of severe liverdisturbances.
>
>Chris van der Linden